Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.9
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin C (as ascorbic acid)
250 mg
278%
*Food BlendOrganic brown rice, organic orange, organic amla fruit, organic rose hip fruit, organic cranberry, organic green bell pepper, organic wild blueberry
536 mg
**

Top Medical Research Studies

We evaluated how vitamin C, also known as ascorbic acid, can help protect the liver during procedures that temporarily cut off blood flow—a process known as ischaemia followed by reperfusion. In this study, we used thirty-six male Wistar rats, split into control groups and experimental ones. Each group received the same total dose of vitamin C, administered at different times: either before the ischaemia, before the reperfusion, or both.

Our findings showed that the animals given vitamin C before both the ischaemia and reperfusion had improved outcomes. They had lower levels of liver enzymes, indicating less liver damage, and showed reduced inflammation. Additionally, their portal blood flow was better when compared to the other groups. Overall, our results suggest that administering vitamin C at specific times can significantly reduce liver injury associated with ischaemia-reperfusion.

This study highlights the potential of vitamin C as a protective agent in situations where liver damage is a concern during surgeries or treatments involving blood flow disruption.
9
L-AP mitigates liver injury
This study investigated how L-ascorbic acid 6-palmitate (L-AP), a derivative of vitamin C, could affect liver injury during sepsis. We focused on understanding its potential to alleviate liver damage caused by an overactive immune response. Through a series of experiments, including the cecal ligation and puncture method in mice, we observed that L-AP significantly increased the survival rates of these animals.

We found that L-AP treatment also reduced liver inflammation, which was evidenced by improved liver tissue health, less liver cell death, and lower levels of liver enzymes in the blood. Interestingly, the effects of L-AP were similar to the results seen in mice that lacked the NLRP3 inflammasome, a key player in inflammation.

Moreover, L-AP appeared to dampen the hyper-inflammatory response characteristic of sepsis. In both the liver tissues and cultured macrophages, we noted a decrease in inflammatory markers linked to the NLRP3 inflammasome pathway. This included lower expression levels of specific inflammatory proteins and less macrophage activation, promoting a more anti-inflammatory response instead.

Overall, our findings reveal that L-AP may help protect the liver during severe bacterial infections by mitigating the harmful effects of macrophage activation and the resultant inflammation. While this study points toward the possible benefits of an ascorbic acid derivative in treating septic liver damage, further investigation is necessary to fully unravel its mechanisms and potential therapeutic applications.
We investigated whether vitamin C could help protect the liver from damage caused by electron beam therapy, a treatment often used for cancers in the abdomen. Our study involved male Wistar rats, which were divided into four groups: one received electron irradiation, one was pre-treated with vitamin C, another received vitamin C alone, and the last group served as a control.

Through detailed analyses, we looked at various markers of liver health, such as liver enzymes and inflammatory cytokines. We also examined the liver tissues of the rats over 90 days to assess any changes. What we found was quite revealing; the group exposed to radiation showed significant liver damage, increased liver enzymes, inflammation, and signs of oxidative stress.

Interestingly, those rats pre-treated with vitamin C experienced milder liver damage and lower levels of oxidative stress and inflammation. This suggests that vitamin C may help maintain a better balance between liver cell growth and cell death, which is crucial after radiation exposure. Overall, our results indicate that vitamin C has potential as a protective agent against radiation-induced liver injury.

Still, while our findings are promising, further research is needed to fully understand the long-term benefits of vitamin C in this context.

Most Useful Reviews

9
Cleansing support
The ingredients are repeated but provide a sufficient amount for cleansing the body. This is an excellent diet for radical detoxification, serving as a strong oxidiser for the liver and presenting numerous benefits.
9
Flu relief
This Vitamin C Complex is one of the best I've tried, and its large quantity lasts for five months. It significantly improved my flu symptoms from the second day, easing discomfort without causing acidity. It is advisable to take it before any surgeries to boost immunity and speed up recovery.
7.5
Immune protection
This vitamin C is excellent for enhancing immunity. I use it for protection against diseases and to aid my quick recovery when I fall ill.

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.9
  • All Researches
9.5
Vitamin C enhances liver cancer treatment
We observed an intriguing case involving a 68-year-old male patient diagnosed with unresectable hepatocellular carcinoma (HCC). This case focused on the potential benefits of incorporating high-dose intravenous vitamin C into the treatment regimen alongside atezolizumab and bevacizumab.

Initially, the patient underwent the combination therapy, but while the imaging showed stable disease, there was only a modest decline in alpha-fetoprotein (AFP) levels. Unfortunately, the patient's condition further declined. In response, a dose of 30 grams of intravenous vitamin C was added to the treatment plan.

Remarkably, this adjustment led to a swift and noteworthy reduction in AFP levels, normalization of liver function tests, and substantial improvement in overall symptoms. Four months later, imaging indicated significant tumor shrinkage and necrosis.

As of 30 months post-diagnosis, the patient benefits from the combined regimen, showing normal liver function and a dramatically reduced AFP level, all while maintaining an active lifestyle. This case demonstrates the potential synergistic effects of high-dose vitamin C in treating unresectable HCC alongside standard therapies, warranting further investigation into such combination approaches.
We evaluated how vitamin C, also known as ascorbic acid, can help protect the liver during procedures that temporarily cut off blood flow—a process known as ischaemia followed by reperfusion. In this study, we used thirty-six male Wistar rats, split into control groups and experimental ones. Each group received the same total dose of vitamin C, administered at different times: either before the ischaemia, before the reperfusion, or both.

Our findings showed that the animals given vitamin C before both the ischaemia and reperfusion had improved outcomes. They had lower levels of liver enzymes, indicating less liver damage, and showed reduced inflammation. Additionally, their portal blood flow was better when compared to the other groups. Overall, our results suggest that administering vitamin C at specific times can significantly reduce liver injury associated with ischaemia-reperfusion.

This study highlights the potential of vitamin C as a protective agent in situations where liver damage is a concern during surgeries or treatments involving blood flow disruption.
9
L-AP mitigates liver injury
This study investigated how L-ascorbic acid 6-palmitate (L-AP), a derivative of vitamin C, could affect liver injury during sepsis. We focused on understanding its potential to alleviate liver damage caused by an overactive immune response. Through a series of experiments, including the cecal ligation and puncture method in mice, we observed that L-AP significantly increased the survival rates of these animals.

We found that L-AP treatment also reduced liver inflammation, which was evidenced by improved liver tissue health, less liver cell death, and lower levels of liver enzymes in the blood. Interestingly, the effects of L-AP were similar to the results seen in mice that lacked the NLRP3 inflammasome, a key player in inflammation.

Moreover, L-AP appeared to dampen the hyper-inflammatory response characteristic of sepsis. In both the liver tissues and cultured macrophages, we noted a decrease in inflammatory markers linked to the NLRP3 inflammasome pathway. This included lower expression levels of specific inflammatory proteins and less macrophage activation, promoting a more anti-inflammatory response instead.

Overall, our findings reveal that L-AP may help protect the liver during severe bacterial infections by mitigating the harmful effects of macrophage activation and the resultant inflammation. While this study points toward the possible benefits of an ascorbic acid derivative in treating septic liver damage, further investigation is necessary to fully unravel its mechanisms and potential therapeutic applications.
8
Dietary antioxidants and liver health
In our exploration of the connection between dietary antioxidants and liver health, we analyzed data from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2020. A key focus was on the composite dietary antioxidant index (CDAI), which includes essential nutrients like vitamin C.

We found that higher CDAI scores were associated with a lower likelihood of developing metabolic dysfunction-associated fatty liver disease (MAFLD). For those in the highest quartile of CDAI, there was a noted 27% reduction in the chance of having MAFLD compared to those in the lowest quartile.

Importantly, changes in vitamin C intake were found to be linked to MAFLD, suggesting that this vitamin may play a role in liver health. Our subgroup analysis particularly highlighted those engaging in moderate-intensity physical activity, reinforcing the idea that a diet rich in antioxidants, including vitamin C, could be beneficial for liver function.

This study opens the door to exploring dietary interventions that potentially reduce the incidence of MAFLD, highlighting the importance of getting enough vitamin C in our diets.
We investigated whether vitamin C could help protect the liver from damage caused by electron beam therapy, a treatment often used for cancers in the abdomen. Our study involved male Wistar rats, which were divided into four groups: one received electron irradiation, one was pre-treated with vitamin C, another received vitamin C alone, and the last group served as a control.

Through detailed analyses, we looked at various markers of liver health, such as liver enzymes and inflammatory cytokines. We also examined the liver tissues of the rats over 90 days to assess any changes. What we found was quite revealing; the group exposed to radiation showed significant liver damage, increased liver enzymes, inflammation, and signs of oxidative stress.

Interestingly, those rats pre-treated with vitamin C experienced milder liver damage and lower levels of oxidative stress and inflammation. This suggests that vitamin C may help maintain a better balance between liver cell growth and cell death, which is crucial after radiation exposure. Overall, our results indicate that vitamin C has potential as a protective agent against radiation-induced liver injury.

Still, while our findings are promising, further research is needed to fully understand the long-term benefits of vitamin C in this context.

User Reviews

USERS' SCORE
Good
Based on 3 Reviews
8.5
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Cleansing support
The ingredients are repeated but provide a sufficient amount for cleansing the body. This is an excellent diet for radical detoxification, serving as a strong oxidiser for the liver and presenting numerous benefits.
9
Flu relief
This Vitamin C Complex is one of the best I've tried, and its large quantity lasts for five months. It significantly improved my flu symptoms from the second day, easing discomfort without causing acidity. It is advisable to take it before any surgeries to boost immunity and speed up recovery.
7.5
Immune protection
This vitamin C is excellent for enhancing immunity. I use it for protection against diseases and to aid my quick recovery when I fall ill.

Frequently Asked Questions

9
Flu relief
This Vitamin C Complex is one of the best I've tried, and its large quantity lasts for five months. It significantly improved my flu symptoms from the second day, easing discomfort without causing acidity. It is advisable to take it before any surgeries to boost immunity and speed up recovery.
7.5
Immune protection
This vitamin C is excellent for enhancing immunity. I use it for protection against diseases and to aid my quick recovery when I fall ill.
9
Cleansing support
The ingredients are repeated but provide a sufficient amount for cleansing the body. This is an excellent diet for radical detoxification, serving as a strong oxidiser for the liver and presenting numerous benefits.
8
Dietary antioxidants and liver health
In our exploration of the connection between dietary antioxidants and liver health, we analyzed data from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2020. A key focus was on the composite dietary antioxidant index (CDAI), which includes essential nutrients like vitamin C.

We found that higher CDAI scores were associated with a lower likelihood of developing metabolic dysfunction-associated fatty liver disease (MAFLD). For those in the highest quartile of CDAI, there was a noted 27% reduction in the chance of having MAFLD compared to those in the lowest quartile.

Importantly, changes in vitamin C intake were found to be linked to MAFLD, suggesting that this vitamin may play a role in liver health. Our subgroup analysis particularly highlighted those engaging in moderate-intensity physical activity, reinforcing the idea that a diet rich in antioxidants, including vitamin C, could be beneficial for liver function.

This study opens the door to exploring dietary interventions that potentially reduce the incidence of MAFLD, highlighting the importance of getting enough vitamin C in our diets.
7
Vitamin C impacts pediatric liver health
We examined how a poor vitamin C status might influence the progression of a specific type of liver disease known as metabolic dysfunction-associated steatohepatitis (MASH) in juvenile guinea pigs. This model is important because children and teenagers often experience unique forms of MASH, yet there is a lack of studies and animal models to fully understand it.

In our study, we conditioned sixty-two young guinea pigs with a high-fat diet for 16 weeks, simulating a scenario that can occur in children. We observed that these young guinea pigs demonstrated liver damage typical of pediatric MASH, including inflammation and fibrosis, but their steatosis levels were noticeably lower compared to adults.

Remarkably, guinea pigs with vitamin C deprivation not only had reduced body weight but also showed elevated levels of inflammatory gene expressions in their livers. This suggests that a deficiency in vitamin C could play a vital role in altering gene expressions linked to liver disease.

While our results indicate a connection between poor vitamin C levels and the progression of pediatric MASH, the study’s limitations prevent us from making direct conclusions about the effectiveness of vitamin C as a standalone treatment. It remains critical to explore the combined effects of nutritional deficiencies, like low vitamin C, on the advancement of liver disease.
7
Vitamin C aids liver protection
We investigated the effects of vitamin C on liver health, particularly how it might help mitigate liver damage caused by methotrexate, a common chemotherapy drug. In our study, we observed Swiss albino mice divided into five groups, with one group receiving vitamin C along with omega-3 fatty acids.

The results were promising; pretreatment with both vitamin C and omega-3 showed a noteworthy ability to lessen liver damage. After assessing the levels of certain enzymes and antioxidants in the blood, we found that the combination treatment significantly reduced oxidative stress markers compared to those that received methotrexate alone.

While each treatment alone played a role, it was the combination that truly stood out. Our findings suggest that vitamin C, especially when paired with omega-3, could offer protective benefits against liver toxicity induced by medications like methotrexate. This adds a dimension to the conversation on managing liver health during such treatments.
We evaluated how vitamin C, also known as ascorbic acid, can help protect the liver during procedures that temporarily cut off blood flow—a process known as ischaemia followed by reperfusion. In this study, we used thirty-six male Wistar rats, split into control groups and experimental ones. Each group received the same total dose of vitamin C, administered at different times: either before the ischaemia, before the reperfusion, or both.

Our findings showed that the animals given vitamin C before both the ischaemia and reperfusion had improved outcomes. They had lower levels of liver enzymes, indicating less liver damage, and showed reduced inflammation. Additionally, their portal blood flow was better when compared to the other groups. Overall, our results suggest that administering vitamin C at specific times can significantly reduce liver injury associated with ischaemia-reperfusion.

This study highlights the potential of vitamin C as a protective agent in situations where liver damage is a concern during surgeries or treatments involving blood flow disruption.

References

  1. Pedersen K, Poojari A, Colberg SF, Mechernsee SM, Iversen JF, et al. A Guinea Pig Model of Pediatric Metabolic Dysfunction-Associated Steatohepatitis: Poor Vitamin C Status May Advance Disease. Nutrients. 2025;17. 10.3390/nu17020291
  2. Dong JX, Jiang LL, Liu YP, Zheng AX. Association between composite dietary antioxidant index and metabolic dysfunction-associated fatty liver disease: a cross-sectional study from NHANES. BMC Gastroenterol. 2024;24:465. 10.1186/s12876-024-03556-6
  3. Demyashkin G, Parshenkov M, Koryakin S, Skovorodko P, Shchekin V, et al. Targeting Oxidative Stress: The Potential of Vitamin C in Protecting against Liver Damage after Electron Beam Therapy. Biomedicines. 2024;12. 10.3390/biomedicines12102195
  4. Mohammed D, Al-Gareeb AM. Evaluation the effects of Omega-3 and vitamin C alone or in combination on Methotrexate-Induced hepatotoxicity (in mice). J Pak Med Assoc. 2024;74:S414. 10.47391/JPMA-BAGH-16-94
  5. Kian W, Remilah AA, Shatat C, Spector M, Roisman LC, et al. Case report: The efficacy of adding high doses of intravenous vitamin C to the combination therapy of atezolizumab and bevacizumab in unresectable HCC. Front Med (Lausanne). 2024;11:1461127. 10.3389/fmed.2024.1461127
  6. Thadeus MS, Susantiningsih T, Muktamiroh H, Fauziah C, Citrawati M, et al. fruit extract as a potential antioxidant against liver injury by 2-Nitropropane induction in obese male mice model: pre-clinical study. F1000Res. 2023;12:300. 10.12688/f1000research.121695.2
  7. Ximenes JLS, Rocha-Filho JA, Galvão FHF, Lanchotte C, Kubrusly MS, et al. The Effect of Ascorbic Acid on Hepatic Ischaemia-Reperfusion Injury in Wistar Rats: An Experimental Study. Int J Mol Sci. 2024;25. 10.3390/ijms25168833
  8. Chen HK, Lan QW, Li YJ, Xin Q, Luo RQ, et al. Association between Dietary Potassium Intake and Nonalcoholic Fatty Liver Disease and Advanced Hepatic Fibrosis in U.S. Adults. Int J Endocrinol. 2024;2024:5588104. 10.1155/2024/5588104
  9. Jaffey JA, Chamberlin T, Hu J. Acute manganese toxicosis related to joint health supplement ingestion in two dogs. Top Companion Anim Med. 2024;61:100877. 10.1016/j.tcam.2024.100877
  10. Liu XH, Chen HK, Luo J, He XP, Zhang WL, et al. Potassium affects the association between dietary intake of vitamin C and NAFLD among adults in the United States. PLoS One. 2024;19:e0295986. 10.1371/journal.pone.0295986
  11. Liu L, Lin L, Wang Y, Yan X, Li R, et al. L-AP Alleviates Liver Injury in Septic Mice by Inhibiting Macrophage Activation via Suppressing NF-κB and NLRP3 Inflammasome/Caspase-1 Signal Pathways. J Agric Food Chem. 2024;72:8460. 10.1021/acs.jafc.3c02781
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